A study of serum malondialdehyde levels and paraoxanase activity in ischemic stroke patients
نویسندگان
چکیده
Stroke is the leading cause of mortality and morbidity world wide, particularly in the elderly. Oxidative stress is an independent risk factor by inducing production of oxygen free radicals in ischemic stroke. Because a relationship may be hypothesized between paraoxanase (PON) and malondialdehyde(MDA),the aim of this study was to investigate the relationship between PON and oxidative stress with ischemic stroke by evaluating MDA concentrations as indexes of oxidative stress. Our study included 100 patients of ischemic stroke and 100 controls.MDA levels was high and antioxidant activity Of PON was low in patients with ischemic stroke as compared to controls. Our findings suggest the importance of assessing the markers of oxidative stress and antioxidant capacity of PON indicating the involvement of lipid peroxidation leading to ischemic stroke.
منابع مشابه
Relationship between paraoxanase activity and lipid levels in ischemic stroke patients
Ischemic stroke is the major killer and is the most important cause of morbidity and mortality world wide. The increasing incidence is due to hypertension, stress of life,obesity, lack of exercise and other factors. We attempted to determine an independent association of paraoxanase with ischemic stroke patients. The lipid profile and serum paraoxanase were investigated in 100 ischemic stroke p...
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